Currently Enrolling Trials
Xdemvy (lotilaner ophthalmic solution) is an ectoparasiticide (anti-parasitic) agent.
Xdemvy is specifically indicated for the treatment of Demodex blepharitis.
Xdemvy is supplied as a solution for topical administration. Instill one drop of Xdemvy in each eye twice daily (approximately 12 hours apart) for 6 weeks. If more than one topical ophthalmic drug is being used, the drugs should be administered at least five (5) minutes apart. If one dose is missed, treatment should continue with the next scheduled dose
Mechanism of Action
Lotilaner is a gamma-aminobutyric acid (GABA)-gated chloride channel inhibitor selective for mites. Inhibition of these GABA chloride channels causes a paralytic action in the target organism leading to its death. Lotilaner is not an inhibitor of mammalian GABA mediated chloride channels when tested at up to 30 µM (18 µg/mL) in vitro (approximately 1100 times the RHOD).
Adverse effects associated with the use of Xdemvy may include, but are not limited to, the following:
- instillation site stinging